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Mexican Meatloaf

This Mexican Meatloaf is an easy, five-ingredient, one-pot wonder. Delicious served over rice or scooped up with chips!

portion of mexican meatloaf with white rice in a floral bowl

I think I have my seasons messed up. I’ve been begging for warmer weather, and it is definitely here, yet I only seem to be cooking cold weather food (like my favorite chicken pot pie). This Mexican Meatloaf is great for a cold night, or a busy week night, or really just for any night!

It’s super easy to make and packed with flavor. We love to scoop it up with tortilla chips or serve it over white rice, but it would also be delicious with a loaf of crusty French bread. I’ve never tried it, but I bet it would be yummy inside lettuce wraps also!  

This recipe freezes well and reheats nicely. It’s definitely going on my list of freezer meals to make before the baby comes. It’s a great casserole for a crowd or to gift to a new Mama.  (Check out this list of my favorite freezer meals for new Moms.)

collage showing how to layer mexican meatloaf

What’s Needed for Mexican Meatloaf? 

To make this quick meatloaf recipe, you’ll need: 

  • Ground beef
  • Cumin
  • Tomato sauce
  • Cream of chicken soup
  • Taco sauce
  • Canned green chiles
  • Tortillas 
  • Shredded cheese 

How to Make Mexican Meatloaf 

  1. Brown the ground beef, drain off any excess fat, then stir in the spices. 
  2. Stir in tomato sauce, soup, taco sauce, and green chiles. 
  3. Line a 9×13-inch baking dish with tortillas, then add the meat mixture. Top with cheese.
  4. Bake until the cheese is bubbly. 

How Long Does it Take to Cook Meatloaf? 

This easy meatloaf recipe needs to bake at 350F for 30 to 35 minutes. 

Can You Freeze Meatloaf? 

Yes!  To freeze: cook as directed, allow to cool, cover with plastic wrap and foil, then freeze. To reheat: thaw in the refrigerator overnight, bake in the oven at 350F until the center is hot (usually up to 45 minutes).

Our Favorite Meatloaf Sides 

Not sure what side dishes to serve with meatloaf? Here are a few of my family’s favorites: 

baked mexican meatloaf in a white casserole dish

Tips for Making Mexican Meatloaf 

  • We prefer using ground beef in this recipe, but I’m sure ground turkey could be substituted. 
  • Use corn or flour tortillas to make this recipe. Both will work! 
  • Note that taco sauce isn’t the same as salsa. I buy the El Paso brand from my local supermarket. 

More Ground Beef Dinner Recipes: 

This Mexican Meatloaf is an easy, five ingredient, one pot wonder. Delicious served over rice or scooped up with chips!

Mexican Meatloaf

3.87 from 15 votes
Print Pin Rate
Prep Time: 15 minutes
Cook Time: 30 minutes
Total Time: 45 minutes
Servings: 6 people
Calories: 679kcal
Author: Emily Grace


  • 2 lbs ground beef
  • 1/2 tsp cumin
  • salt and pepper
  • Cayenne (optional)
  • 10 oz small can of tomato sauce
  • 10 3/4 oz can cream of chicken soup
  • 10 3/4 oz can chicken and rice soup
  • 8 oz taco sauce
  • 4 oz green chilis
  • 8 Tortillas
  • 2 cups shredded cheese


  • Preheat oven to 350 degrees F.
  • Brown the meat until fully cooked. Drain, and add the spices.
  • Add all other ingredients and mix well.
  • Line a baking dish with tortillas. (I like to tear mine in half first)
  • Fill the pan with the meat sauce mixture.
  • Top generously with cheese.
  • Bake for 30-35 minutes, until cheese is bubbly.


Note: The nutritional facts do not include the taco sauce or chicken and rice soup as the information was not in my database. 


Serving: 1serving | Calories: 679kcal | Carbohydrates: 28g | Protein: 39g | Fat: 44g | Saturated Fat: 18g | Cholesterol: 140mg | Sodium: 1277mg | Potassium: 679mg | Fiber: 2g | Sugar: 5g | Vitamin A: 550IU | Vitamin C: 5.6mg | Calcium: 271mg | Iron: 5.6mg
Did you make this recipe? Mention @GraceGoodEats or tag #graceandgoodeats!
3.87 from 15 votes (13 ratings without comment)
Recipe Rating


Saturday 1st of September 2018

What are the freezer instructions for this recipe?

Emily Grace

Wednesday 19th of September 2018

Hi Danielle, to freeze: cook as directed, allow to cool, freeze. To reheat- thaw in the refrigerator overnight, bake in the oven 350 degrees until the center is hot (usually up to 45 minutes).


Sunday 5th of August 2018

Looks delicious! What exactly is taco sauce? Salsa? Thanks for touching base!

Emily Grace

Wednesday 8th of August 2018

Search for "Old El Paso Taco Sauce" that's the brand I use and it comes in a jar. Different than salsa.


Monday 22nd of January 2018

Do you have freezer instructions for this? Looks so yummy!


Friday 24th of November 2017

My family really enjoyed this!

Emily Grace

Wednesday 29th of November 2017

Glad to hear that, Samantha!


Monday 17th of April 2017

This was so good with chips! I love adding sliced jalapenos on top.

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